Treyarch made one last World War II-based game, World at War (2008), before releasing Black Ops (2010) and subsequently creating the Black Ops sub-series. Infinity Ward have also developed two games outside of the Modern Warfare sub-series, Ghosts (2013) and Infinite Warfare (2016). The sub-series received a reboot with Modern Warfare in 2019. Two other entries, Modern Warfare 2 (2009) and 3 (2011), were made. The game's legacy also influenced the creation of a remastered version, released in 2016. Call of Duty 4: Modern Warfare (2007) introduced a new, modern setting, and proved to be the breakthrough title for the series, creating the Modern Warfare sub-series. The series originally focused on the World War II setting, with Infinity Ward developing the first (2003) and second (2005) titles in the series and Treyarch developing the third (2006). The next title, Call of Duty: Vanguard, will be released on November 5, 2021. The most recent title, Call of Duty: Black Ops Cold War, was released on November 13, 2020.

Several spin-off and handheld games were made by other developers. The games were first developed by Infinity Ward, then also by Treyarch and Sledgehammer Games. Over time, the series has seen games set in the midst of the Cold War, futuristic worlds, and outer space. Starting out in 2003, it first focused on games set in World War II. Call of Duty is a first-person shooter video game franchise published by Activision.

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